Enterprise DNA

Instead of CRIO

Stop renting CRIO. Own your trial site system.

We build your version around your studies, budgets and SOPs, bring your CRIO subject and visit history across, and run it for you.

CRIO does not publish a price; you get a quote after a demo. Rival SimpleTrials lists its site plan at $599 a month, plus a startup fee.

Get your version built See it working
  • check_circleYour data in a database you own
  • check_circleOpen source, no lock-in
  • check_circleBuilt and run by Enterprise DNA

What the subscription covers

Most of a site platform is arithmetic over your own records

CRIO sells eSource, site CTMS, eRegulatory, payments, recruitment and eConsent as one platform. Strip out bedside data capture and what is left is dates, money and documents.

request_quote

A price you only see after a demo

CRIO lists no price on its site. Rivals that do publish charge $599 a month for a site plan, before the startup fee.

event

Visit window tracking

Sold as automated window tracking. Underneath it is the baseline date plus the protocol day, give or take the window.

payments

Invoicing from completed visits

CRIO generates invoices from completed visit data. That is a sum of completed visits against your trial budget.

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The regulatory binder

Approvals, consent versions, insurance and staff certificates. A list of documents with versions and expiry dates.

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Reports and a report builder

Standard reports, a report builder and a custom report service. Your own database answers the same questions when you ask.

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Recruitment and stipend add-ons

Text blasts, prescreening questionnaires and stipend cards. We connect the providers you already use into your version.

Your version

What the site team gets instead

Schedule

Every visit window, worked out

Enrol a participant and every visit in the schedule of assessments is laid out with its window.

  • check Overdue, open and upcoming windows in one list each morning
  • check A visit outside its window is flagged until a deviation is recorded
  • check Which participants have run late before and have a visit due
  • check Visit loads by coordinator for the next 30 days

Money

Every completed visit invoiced

A completed visit earns its fee from the budget the moment it is recorded.

  • check Earned and not invoiced, by study and by age
  • check One invoice per study for everything outstanding
  • check Which sponsors pay slowest against their own terms
  • check Screen failures with no fee recorded, so nothing is left unclaimed

Binder

Ready for a monitor or an inspection

The delegation log, staff training and essential documents are checked against the visits actually done.

  • check A visit by someone not delegated for visits that day
  • check GCP training older than your SOP allows
  • check Expired insurance or registrations with no renewal on file
  • check Progress reports to the ethics committee coming due

Safety

Clocks nobody can miss

The serious adverse event clock starts when the site becomes aware, and it leads every list until the sponsor is told.

  • check Hours left to report each serious adverse event
  • check Visits done before consent was signed
  • check Participants still on an old consent form version
  • check Each finding names the rule and where it comes from

Make it yours

Design your own CRIO replacement

Everything starts from the open-source base. Then it gets your name, the parts you run, your rules and your data from CRIO. Try it here, and we build the real one.

2. What it runs

3. Make it fit

4. Your colour

Your business · your CRIO replacement Your version
YB Your business

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Answered from your own database

Build my version

We build it from the open-source base, bring your CRIO data across and run it for you.

What it looks like

Ask it like you would ask a colleague

Real answers from the demo data that ships with Trial Site for Claude Code. It runs in Claude Code inside the Claude app, so it feels like any chat you already use.

forum

Trial Site for Claude Code

Connected to your own database

What needs someone at the site today?

SAE CLOCK

Protocol
KES-210
Record
210-003
Owner
Principal investigator
Due date
2026-10-16
Detail
Serious event not reported to sponsor: Hospitalised with syncope

VISIT OVERDUE

Protocol
MER-301
Record
301-001 Week 16
Owner
Mele Taufa
Due date
2026-10-15
Detail
Window closed 2026-10-15

VISIT DUE

Protocol
MER-301
Record
301-002 Week 8
Owner
Mele Taufa
Due date
2026-10-17
Detail
Window open 2026-10-07 to 2026-10-17

VISIT DUE

Protocol
KES-210
Record
210-003 Day 90 check
Owner
Mele Taufa
Due date
2026-10-20
Detail
Window open 2026-09-22 to 2026-10-20

VISIT DUE

Protocol
KES-210
Record
210-002 Day 180 final
Owner
Mele Taufa
Due date
2026-11-09
Detail
Window open 2026-10-12 to 2026-11-09

INVOICE OVERDUE

Protocol
MER-301
Record
Invoice MER301-0007
Owner
Meridian Therapeutics
Due date
2026-08-02
Detail
1250 AUD, 30 days past due

NOT INVOICED

Protocol
KES-210
Record
210-003 Implant
Owner
Finance
Due date
2026-07-08
Detail
3200 USD earned 100 days ago

NOT INVOICED

Protocol
KES-210
Record
210-003 Day 30 check
Owner
Finance
Due date
2026-08-05
Detail
950 USD earned 72 days ago

NOT INVOICED

Protocol
MER-301
Record
301-001 Week 8
Owner
Finance
Due date
2026-08-13
Detail
1250 AUD earned 64 days ago

NOT INVOICED

Protocol
MER-301
Record
301-002 Screening
Owner
Finance
Due date
2026-08-13
Detail
1450 AUD earned 64 days ago

Ask it anything

Ten questions your version answers today

CRIO offers standard reports and a report builder. Here these questions are built into the free version, and you can ask your own in plain English.

chat_bubble Which sponsors pay us slowest, against their own payment terms?
chat_bubble How much have we earned and not yet invoiced, by study and age?
chat_bubble Which studies are behind their enrolment pace?
chat_bubble Which referral sources bring participants who actually enrol?
chat_bubble Who has run the most visits outside the protocol window?
chat_bubble What is each study's screen failure rate, and which screen failures have no fee recorded?
chat_bubble Which participants have a visit due in the next 14 days and have missed or run late before?
chat_bubble Which studies have the most protocol deviations per enrolled participant?
chat_bubble Which coordinators carry the most visit windows in the next 30 days?
chat_bubble How much has each study earned per enrolled participant against the full schedule value?

Switching

How to switch from CRIO

A move usually involves preparing two CRIO reports, mapping your studies and visit schedules, testing the import, then checking records before you switch.

  1. 1

    Export subjects and visits

    Use CRIO’s standard reports or report builder to prepare one report with a row per subject and another with a row per visit. Download them as CSV, study by study. Check with CRIO if you need help finding the reports or confirming what your account allows you to export. Source documents, binder files, audit trails and payment history do not come across in this version.

  2. 2

    Set up studies and schedules

    Before loading records, add each study and its schedule of assessments to Trial Site. This gives the import a schedule to match visits against. Visits match by code or name, and anything that does not match comes in as an unscheduled visit. Decide which studies and history you want to bring across, knowing that the import covers subjects and visits.

  3. 3

    Test the import first

    Run a test import for a study before loading its records for real. Review what the test reports and correct any field mapping or schedule issues you find. Then import the subject and visit reports study by study. The import uses the subject ID to update matching records, so you can run it again if you need to correct or add data.

  4. 4

    Check records against your rules

    After importing, check the participant and visit records against your study information and SOPs. Review the record checks for gaps such as visits before consent, visits outside their protocol window, or visits performed by staff without delegation. Resolve issues that come from missing or mismatched data, and confirm that visit fees and other imported details are right before relying on the new system.

  5. 5

    Run both systems, then switch

    Keep CRIO and Trial Site in use side by side for a short period you agree on. Compare current study, participant, visit and fee records, and make sure your team can find what it needs in Trial Site. Once you are satisfied with the checks and the agreed records are in place, switch off CRIO for the operations you have moved. Keep source data and documents where your SOPs require them.

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Where the real effort goes

The main work is usually mapping your own fields, study schedules and rules, then deciding how much history to bring. The import covers subjects and visits, not source documents, binder files, audit trails or payment history, so plan where those records will remain. If you have Enterprise DNA run the system, they handle this migration work with you as part of agreeing the scope.

Not ready for a call?

Get your CRIO switch plan by email

We will send you the step-by-step plan for moving your business off CRIO, what the move really involves, and how we would do it for you.

One email with your plan. No spam, and you can unsubscribe any time.

Three ways to own it

Start with the free version or have your site’s version built

Open source

Do it yourself

Free code; hosting and agent costs are yours

  1. 1 Clone the repo and run npm install, then npm run demo
  2. 2 Open it in Claude Code, Codex, OpenCode or Cursor
  3. 3 Add your studies and each schedule of assessments
  4. 4 Import your CRIO subject and visit reports with a dry run first
Get it on GitHub

Built around your business

We customise it

One setup fee, then a retainer

  • check Your budgets, visit fees, SOP intervals and document types
  • check Your CRIO subject and visit history mapped and brought across
  • check A web front end, recruitment texts or stipend payments connected if you want them
  • check Your accounting system fed from the invoices
Get your version built

Omni by Enterprise DNA

We run it for you

One setup fee, then a retainer

  • check Installed, hosted and operated through Omni by Enterprise DNA
  • check Access controls and backups agreed for your site
  • check A Monday review of safety clocks, visits and money waiting for the site manager
  • check Changes as studies open, amend and close
Book a call

Questions

Instead of CRIO, answered

Does this replace CRIO’s eSource? expand_more

No. The free version is the business side of the site: schedule, money, binder, delegation and safety clocks. Source data and case report forms stay in the sponsor’s system, on paper, or in a source tool you keep. Many sites move the operations side and keep source where it is.

Can we bring our CRIO records across? expand_more

CRIO offers standard reports and a report builder. A report with a row per subject and one with a row per visit, downloaded as a spreadsheet, brings participants, visits and visit fees across. Source documents, binder files and audit trails stay where they are. We agree the scope and do a test run before you switch.

Does it meet good clinical practice? expand_more

It checks your records against the rules and flags gaps: late serious event reports, visits before consent, undelegated staff, overdue progress reports. Each finding cites its source. Your site stays responsible for its quality system, and anything holding source data needs validation under it.

Where does participant information live? expand_more

In a database your site owns, hosted where you choose, including Australia or New Zealand. The free version stores subject numbers and initials, not full names. We set access and backups with you in the version we run.

What do we pay Enterprise DNA? expand_more

One setup fee, then a retainer for the agreed customisation and operation. We review your studies, budgets and history with you before setting the scope. The free code has no licence fee; hosting and your chosen assistant have their own costs.

Build it around how your site runs

Spend 30 minutes with Sam. Bring your CRIO quote, one study’s budget and the report you wish you had. We will map the version you need and the records to bring across.

Book a call with Sam Get the free version

Trial Site for Claude Code is free and open source, published by Enterprise DNA.

Done paying for CRIO?

Get your version built